Background and Aim: Ascorbic Acid (vitamin C) is a white powder and non-toxic. VC is the most important antioxidant. This vitamin is not stable enough in aqueous solution. The aim of this work is to encapsulate Ascorbic Acid within nanomicelle in order to increase the stability of vitamin, fat-solu-.ble and higher concentrations drug delivery Materials and Methods: Using surfactant Tween 80 and α-tocopherol in stable temperature conditions, nanomicelle was developed. Encapsulation efficiency was calculated by spectrophotometric method. The morphology of nanomicelle was examined with electron microscope TEM operating and Size measurements of the samples were obtained by Dynamic Light Scattering Instrument (Na-.) no-ZS; Malvern, UK Results: The mean diameter and encapsulation efficiency of nanomicelle Ascorbic Acid is, respective-.ly, 100 nm and 70% Conclusion: This study showed that Ascorbic Acid can be encapsulated into nanomicelle and protected against environmental factors such as temperature, humidity, pH and light; also with this method .the fat-solubility of vitamin can be achieved.

Methemoglobinemia is a disorder characterized by the presence of a higher than normal level of methemoglobin. Prilocaine which is one of the oxidizing local anaesthetics is widely used in many local procedures. The first choice of treatment of complications due to the use of these local anaesthetics is methylene blue, while Ascorbic Acid is the alternative choice. The side effects of metilen blue restrict its usage in some special conditions. Ascorbic Acid is a good alternative drug with limited experience in methemoglobinemia. We present a case of a methemoglobinemia treated with Ascorbic Acid successfully to emphasize the use of Ascorbic Acid as an alternative method.